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Fully sequenced samples of complimentary DNA synthesized from single-stranded, mammalian RNA. Various gene inserts sourced from humans, mice, monkeys, and other species are available. Ideal for use in gene cloning, as gene probes, and in cDNA library creation.
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This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate The binding sites for each ligand are located on different segments of the protein This receptor has various functions including in the intracellular trafficking of lysosomal enzymes the activation of transforming growth factor beta and the degradation of insulin-like growth factor 2 Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele however imprinting of the human gene may be polymorphic as only a minority of individuals showed biased expression from the maternal allele (PMID 8267611)
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Zyagen Mouse Universal Reference cDNA is a full length first strand cDNA synthesized from Zyagen universal reference RNA which is isolated from wide variety of male and female tissues. The cDNA is primed with oligo dT and can be used in gene cloning, target sequencing and as a control for gene expression analysis by regular PCR and real time PCR. Each cDNA product is enough for 40 PCR reactions. Features: Synthesized from high quality intact universal reference total RNA. Consistent control for standard data set comparisons. Prepared from several major tissues for broad gene coverage. Made at industrial scales to minimize lot-to-lot variation. Quality Control: The integrity of each RNA sample used for cDNA synthesis is verified by denatured agarose gel electrophoresis. The purity of RNA is assessed by NanoDrop (A260/A280: 1.9-2.1). Residual DNA contamination is tested by PCR. The synthesized cDNA is also used as template PCR amplification of ß-actin gene.
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Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity Involved in negative regulation of cardiac muscle cell differentiation Acts upstream of or within fibroblast growth factor receptor signaling pathway Located in adherens junction Biomarker of renal cell carcinoma
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